Profhilo has become one of the most talked-about skin treatments in the UK, and one of the first questions people ask is simple: how much...
Polynucleotide treatment has grown in popularity as a way to improve skin quality, particularly in delicate areas such as under the eyes. If you are thinking about having it, it helps to know what recovery looks like and which side effects are normal. This guide covers what to expect, how to look after your skin and when to seek advice.
What Is Polynucleotide Treatment?
Polynucleotides are highly purified fragments of DNA, typically derived from salmon, that are injected into the skin. They support the skin’s natural repair processes, helping to improve hydration, elasticity and the look of fine lines. Unlike a filler, the aim is not to add volume but to improve the quality of the skin itself. Read more on our polynucleotide treatment page.
Common Side Effects
Most side effects are mild and short-lived, and are linked to the injection process itself rather than the product.
- Redness and tenderness: Usually settles within a day or two.
- Small bumps: Tiny raised areas at the injection points are common and typically flatten within a day or so.
- Bruising: Can occur, especially in thinner skin areas, and usually fades within a week.
- Mild swelling: More noticeable around the eyes, and normally resolves within a few days.
Is There Any Downtime?
Downtime is generally minimal. Most people return to normal activities straight away, although you may prefer to avoid important social events for a couple of days if you bruise easily. Because results build gradually, you will not see the full effect straight after treatment.
Aftercare Tips
In the first 24 to 48 hours
Avoid touching or rubbing the treated area, and skip make-up for the period your practitioner advises. Avoid strenuous exercise, saunas and steam rooms, which can increase swelling and redness.
In the following days
Keep skin hydrated, use a gentle cleanser and apply sun protection daily. Avoid alcohol for a short time if you are prone to bruising.
When Will You See Results?
Skin quality usually improves gradually over several weeks as the skin responds. Most people have a course of sessions, spaced a few weeks apart, with maintenance as needed. For some concerns, polynucleotides can be paired with other skin-boosting options such as Profhilo to address different aspects of skin quality.
Who Should Avoid It?
Polynucleotide treatment may not be suitable if you are pregnant or breastfeeding, have an active skin infection in the area, or have a known allergy to fish-derived products. A consultation will cover your medical history to make sure it is safe for you.
When to Seek Advice
Contact your practitioner if you notice increasing pain, spreading redness, heat, or any signs of infection after treatment. These are uncommon, but prompt advice is always best.
Polynucleotides Under the Eyes
Under-eye skin is thin and delicate, so it can show bruising or swelling more easily than other areas. For this reason, your practitioner will use a careful technique and may advise a slightly longer healing window. Gentle handling and avoiding rubbing the area make a noticeable difference to how quickly it settles.
How Does It Compare With Other Treatments?
Polynucleotides are often compared with hyaluronic acid skin boosters. Both aim to improve skin quality, but they work in different ways: polynucleotides support the skin’s own repair processes, while hyaluronic acid draws in and holds moisture. Neither adds noticeable volume, so if hollowing is your main concern, a filler may suit you better. A consultation will help you choose the best match, or whether a combination makes sense.
How Many Sessions Are Needed?
Most people start with a course of around three sessions a few weeks apart, then have maintenance treatments as advised. The exact plan depends on your skin, your goals and how well you respond. Results build over time, so patience is important, and your practitioner can review progress with you as you go.
Tips for a Smooth Recovery
- Plan ahead: Book your session a few days before any major event, in case of bruising.
- Stay hydrated: Good hydration supports healing skin.
- Be patient: Small bumps and mild redness are normal and settle quickly.
- Follow advice: Aftercare guidance is there to protect both safety and results.
Book a Consultation With Dr Leonardo Fasano
The best way to find out what is right for you is a personal assessment. Dr Leonardo Fasano will talk through your concerns, explain your options honestly and recommend a plan tailored to you. To get started, book a consultation at our London or Birmingham clinic.
